Présentation générale

Equipe Ingénierie Moléculaire

2006-
2001-2005

Equipe Biochimie Pharmacologique

Webmaster :
Stéphanie HESSE

Publications Biochimie Pharmacologique

2011 (5)

Bioorg Med Chem. 2011 Dec 30. [Epub ahead of print]
Saidu NE, Valente S, Bana E, Kirsch G, Bagrel D, Montenarh M.
Coumarin polysulfides inhibit cell growth and induce apoptosis in HCT116 colon cancer cells.

Chem Res Toxicol. 2011 Dec 12. [Epub ahead of print]
Jacob C, Battaglia E, Burkholz T, Peng D, Bagrel D, Montenarh M.
Control of Oxidative Posttranslational Cysteine Modifications: From Intricate Chemistry to Widespread Biological and Medical Applications.

"Breast Cancer: Focusing Tumor Microenvironment, Stem Cells And Metastasis", 1991, 584 pages, www.intechopen.com, Mehmet Gunduz and Esra Gunduz Editors,.In Tech Publisher, pp21-38.
Emilie Bana and Denyse Bagrel
In Vitro Breast Cancer Models as Useful Tools in Therapeutics?

Clin Chem Lab Med. 2011, 49(10):1707-14
Albert H, Santos S, Battaglia E, Brito M, Monteiro C, Bagrel D.
Differential expression of CDC25 phosphatases splice variants in human breast cancer cells.

Int J Oncol. 2011;38(4):1103-11
Viry E, Anwar A, Kirsch G, Jacob C, Diederich M, Bagrel D
Antiproliferative effect of natural tetrasulfides in human breast cancer cells is mediated through the inhibition of the cell division cycle 25 phosphatase

2010 (1)

Bioorg Med Chem Lett. 2010;20(19):5827-30
Valente S, Bana E, Viry E, Bagrel D, Kirsch G.
Synthesis and biological evaluation of novel coumarin-based inhibitors of Cdc25 phosphatases.

2009 (3)

Oncol Rep. 2009 , 21(6):1551-8.
Malta-Vacas J, Chauvin C, Gonçalves L, Nazaré A, Carvalho C, Monteiro C,
Bagrel D, Jean-Jean O, Brito M.
eRF3a/GSPT1 12-GGC allele increases the susceptibility for breast cancer development.

Endocrinology. 2009, 150(3):1192-201
El Kebbaj Z, Andreoletti P, Mountassif D, Kabine M, Schohn H, Dauça M, Latruffe N, El Kebbaj MS, Cherkaoui-Malki M.
Differential regulation of peroxisome proliferator-activated receptor(PPAR)-{alpha}1 and truncated PPAR{alpha}2 as an adaptive response to fasting in the control of hepatic peroxisomal fatty acid {beta}-oxidation in the hibernating mammal.

Eur J Med Chem. 2009 44(6):2724-30.
Tzanova T, Gerova M, Petrov O, Karaivanova M, Bagrel D.
Synthesis and antioxidant potential of novel synthetic benzophenone analogues.

2008 (7)

Toxicol In Vitro. 2008, 22(6):1547-54
Baigi MG, Brault L, Néguesque A, Beley M, Hilali RE, Gaüzère F, Bagrel D.
Apoptosis/necrosis switch in two different cancer cell lines: influence of benzoquinone- and hydrogen peroxide-induced oxidative stress intensity, and glutathione.

Bioorg Med Chem Lett. 2008, 18(3):1102-5
Beillerot A, Domínguez JC, Kirsch G, Bagrel D.
Synthesis and protective effects of coumarin derivatives against oxidative stress induced by doxorubicin.

Life Sci. 2008, 82(5-6):315-23
Brault L, Bagrel D.
Activity of novel Cdc25 inhibitors and preliminary evaluation of their potentiation of chemotherapeutic drugs in human breast cancer cells.

J Cardiovasc Pharmacol. 2008, 51(3):304-10
Chan SL, Tabellion A, Bagrel D, Perrin-Sarrado C, Capdeville-Atkinson C,
Atkinson J.
Impact of chronic treatment with red wine polyphenols (RWP) on cerebral arterioles in the spontaneous hypertensive rat.

Int J Mol Med. 2008, 22(6):825-32
Fiatte C, Huin C, Collet P, Plénat F, Dauça M, Schohn H.
Expression of PPARgamma is reduced by medium supplementation with L-glutamine in human colorectal Caco-2 cells.

Drug Metab Dispos. 2008, 36(2):260-7
Osbild S, Bour J, Maunit B, Guillaume C, Asensio C, Muller JF, Netter P, Kirsch G, Bagrel D, Lapicque F, Battaglia E.
Interaction of the electrophilic ketoprofenyl-glucuronide and ketoprofenyl-coenzyme A conjugates with cytosolic glutathione S-transferases.

Chem Med Chem. 2008, 3(11):1667-70
Viry E, Battaglia E, Deborde V, Müller T, Réau R, Davioud-Charvet E, Bagrel D.
A sugar-modified phosphole gold complex with antiproliferative properties acting as a thioredoxin reductase inhibitor in MCF-7 cells.

2007 (5)

Neurosci Lett. 2007, 418(2):159-64
Amazzal L, Lapôtre A, Quignon F, Bagrel D.
Mangiferin protects against 1-methyl-4-phenylpyridinium toxicity mediated by oxidative stress in N2A cells.

Fundam Clin Pharmacol. 2007, 21(3):273-9
Lartaud I, Faure S, Tabellion A, Resende AC, Nadaud S, Bagrel D, Capdeville-Atkinson C, Atkinson J.
Melatonin counteracts the loss of agonist-evoked contraction of aortic rings induced by incubation.

Med Sci (Paris). 2007, 23(5):515-8
Murad H, Fiatte C, Brunner E, Huin-Schohn C, Schohn H, Bécuwe P, Domenjoud L, Dauça M.
[PPARs and cell-cell or cell-extracellular matrix interactions]

Biochimie. 2007, 89(3):329-36
Murad H, Collet P, Brunner E, Schohn H, Bécuwe P, Devignes MD, Dauça M, Domenjoud L.
Immunoselection and characterization of a human genomic PPAR binding fragment located within POTE genes.

Eur J Med Chem. 2007, 42(2):243-7
Brault L, Denancé M, Banaszak E, El Maadidi S, Battaglia E, Bagrel D, Samadi M.
Synthesis and biological evaluation of dialkylsubstituted maleic anhydrides as
novel inhibitors of Cdc25 dual specificity phosphatases.

2006 (3)

Anticancer Res. 2006, 26(5A):3595-600
Osbild S, Brault L, Battaglia E, Bagrel D.
Resistance to cisplatin and adriamycin is associated with the inhibition of glutathione efflux in MCF-7-derived cells.

Int J Oncol. 2006, 28(4):977-84
Murad H, Collet P, Huin-Schohn C, Al-Makdissy N, Kerjan G, Chedotal A, Donner M, Devignes MD, Becuwe P, Schohn H, Domenjoud L, Dauça M.
Effects of PPAR and RXR ligands in semaphorin 6B gene expression of human MCF-7 breast cancer cells.

Int J Oncol. 2006, 29(6):1601-10
Fiatte C, Huin C, Bertin I, Lesuffleur T, Pluvinet A, Touche N, Plénat F,Dauça M, Domenjoud L, Schohn H.
Genetic analysis of peroxisome proliferator-activated receptor gamma1 splice variants in human colorectal cell lines.

2005 (4)

Eur J Med Chem. 2005, 40(8):757-63
Brault L, Migianu E, Néguesque A, Battaglia E, Bagrel D, Kirsch G.
New thiophene analogues of kenpaullone: synthesis and biological evaluation in breast cancer cells.

Clin Chem Lab Med. 2005, 43(2):151-6
Gonçalves J, Malta-Vacas J, Louis M, Brault L, Bagrel D, Monteiro C, Brito M.
Modulation of translation factor's gene expression by histone deacetylase inhibitors in breast cancer cells.

Int J Oncol. 2005, 26(6):1569-74
Louis M, Rosato RR, Battaglia E, Néguesque A, Lapotre A, Grant S, Bagrel D.
Modulation of sensitivity to doxorubicin by the histone deacetylase inhibitor sodium butyrate in breast cancer cells.

Hypertension. 2005, 46(2):372-9
Gaillard V, Casellas D, Seguin-Devaux C, Schohn H, Dauça M, Atkinson J,
Lartaud I.
Pioglitazone improves aortic wall elasticity in a rat model of elastocalcinotic
arteriosclerosis.

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