Présentation générale

Equipe Ingénierie Moléculaire

2006-2009
2001-2005

Equipe Biochimie Pharmacologique

Webmaster :
Stéphanie HESSE

Publications Ingénierie Moléculaire à partir de 2006

2012 (1)

Arkivoc 2012 (iii) 431-441
P. Seck, D. thomae, E. Perspicace, S. Hesse, G. Kirsch
Synthesis of new selenophene and thiazole analogues of the Tacrine series

2011 (4)

Tetrahedron 2011, 9352-9357
G. Revelant, S. Hesse, G. Kirsch
Synthesis of novel 2-amino-thieno[3,2-d]thiazoles and selenolo[3,2-d]thiazoles

Synthesis 2011, 2935-2940
G. Revelant, S. Dunand, S. Hesse, G. kirsch
Microwave-assisted synthesis of 5-substituted-2-aminothiophenes starting from arylacetaldehydes

Tetrahedron Letters 2011, 3429-3432
S. Valente, G. Kirsch
Facile synthesis of 4-acetyl-coumarins, -thiocoumarin and -quinolin-2(1H)-one via very high alpha-regioselective Heck coupling on tosylates

Synthesis 2011, 1314-1318
I Abdillahi, G. Kirsch
Synthesis of a series of novel thieno and benzothieno[3.2-d]pyrimidin-4-ones

2010 (8)

Bioorg Med Chem Lett. 2010, 5827-5830
Valente S, Bana E, Viry E, Bagrel D, Kirsch G.
Synthesis and biological evaluation of novel coumarin-based inhibitors of Cdc25 phosphatases.

Synthesis 2010, 3319-3324
G. Revelant, S. Hesse, G. Kirsch
Synthesis of novel N-substituted 2-(hetero)arylimino-1,3-thiazolidin-4-ones

Arkivoc 2010, 323-329
Kamga J, Sandjo LP, Poumale HM, Ngameni B, Shiono Y, Yemloul M, Rincheval V, Ngadjui BT, Kirsch G.
Politamide, a new constituent from the stem bark of Ficus polita Vahl (Moraceae)

Synthesis 2010, 2543
I. Abdillahi, G. Revelant, Y. Datoussaid, G. Kirsch
Synthesis of novel 2-thienylimino-1,3-thiazolidin-4-ones

Synthesis 2010, 2413-2418
B. Chen, E. Perspicace, S. Hesse, G. Kirsch
Microwave-assisted synthesis of 4-amino-2-arylthieno[2,3-d]pyrimidines and their subsequent functionalization

Synthesis 2010, 1428-1430
I. Abdillahi, G. Kirsch
Synthesis of a novel series of thieno[3,2-d]pyrimidin-4-ones

Dyes and pigments 2010, 86, 217-226
C. Herbivo, A. Comel, G. Kirsch, A.M.C. Fonseca,M. Belsley, M.M.M. Raposo
Synthesis And Characterization Of Novel Efficient And Thermally Stable 2-Aryl-5-Dicyanovinylthiophenes And 5-Aryl-5´-Dicyanovinyl-2,2´-Bithiophenes As Potentially Promising Nonlinear Optical (NLO) Materials

Journal of Organic Chemistry 2010, 839-847
G. Bentabed-Ababsa, S. Cheikh Sid Ely, S. Hesse, E. Nassar, F. Chevallier, T.T. Nguyen, A. Derdour, F. Mongin
Direct metalation of heteroaromatic esters and nitriles using a mixed lithium-cadmium base. Subsequent conversion to dipyridopyrimidinones

2009 (9)

Tetrahedron 2009, 65, 10453-10458
D. Thomae, E. Perspicace, D. Henryon, Z. Xu, S. Schneider, S. Hesse, G. Kirsch, P. Seck
One pot synthesis of new tetrasubtituted thiophenes and selenophenes

Organic Biomolecular Chemistry 2009, 7, 4782-4788
K. Snégaroff, F. Lassagne, G. Bentabed-Ababsa, E. Nassar, S. Cheikh Sid Ely, S. Hesse, E. Perspicace, A. Derdour, F. Mongin
Direct metallation of thienopyrimidines using a mixed Li-Cd base

Synthesis 2009, 3472-3476
E. Perspicace, D. Thomae, G. Hamm, S. Hesse, G. Kirsch
Synthesis of substituted selenolo[3,2-d][1,2,3]triazines and [1,3]selenazolo[4,5-d][1,2,3]triazines

Synthesis 2009, 2345-2348
J.C. Rodriguez Dominguez, X. Gang, G. Kirsch
The Ullmann coupling between some 2-chlorobenzoic acids and amino acids, a valuable reaction for preparing some 2-substituted-1-acetyl-1H-indol-3-yl-acetates.

J. Het. Chem. 2009, 46, 459-464
E. Perspicace, S. Hesse, G. Kirsch, M. Yemloul, C. Lecomte
Unexpected C-O bond formation in Suzuki coupling of 4-chlorothieno[2,3-d]pyrimidines

Synthesis 2009, 1204-1208
S. Hesse, C. Chenet, D. Thomae, G. Kirsch
Microwave-assisted synthesis and functionalization of selenolopyrimidines

Tetrahedron 2009, 2982-2988
D. Thomae, E. Perspicace, Z. Xu, D. Henryon, S. Schneider, S. Hesse, G. Kirsch, P. Seck
One-pot synthesis of new 2,4,5-trisubstituted 1,3-thiazoles and 1,3-selenazoles

Tetrahedron 2009, 2079-2086
C. Herbivo, A. Comel, G. Kirsch, M. Raposo
Synthesis of 5-aryl-50-formyl-2,20-bithiophenes as new precursors for nonlinear optical (NLO) materials

Helv Chim Acta 2009,92(9),1748-1759
Sandjo LP, Simo IK, Kuete V, Hannewald P, Yemloul M, Rincheval V, Ngadjui BT, Kirsch G, Couty F, Schneider S.
Triumfettosterol Id and Triumfettosaponin, a New (Fatty Acyl)-Substituted Steroid and a Triterpenoid 'Dimer' Bis(beta-D-glucopyranosyl) Ester from the Leaves of Wild Triumfetta cordifolia A. RICH. (Tiliaceae)

2008 (12)

Bioorg. Med. Chem. 2008, 8172-8177
E. Pinto, M.-J.R.P. Queiroz, L.A. Vale-Silva, J.F. Oliveira, A. Begouin, J.-M. Begouin, G. Kirsch
Antifungal activity of synthetic di(hetero)arylamines based on the benzo[b]thiophene moiety

Magn Reson Chem 2008,46(10), 939-942
Yemloul M, Bouguet-Bonnet S, Ba LA, Kirsch G, Canet D.
Selective HOESY experiments for stereochemical determinations.

Tetrahedron 2008, 9309-9314
D. Thomae, E. Perspicace, S. Hesse, G. Kirsch, P. Seck
Synthesis of substituted [1,3]thiazolo[4,5-b]pyridines and [1,3]thiazolo[4,5-d][1,2,3]triazines

Helvetica Chimica Acta 2008, 91, 1326-1335
L.P. Sandjo, P. Hannewald, M. Yemloul, G. Kirsch, B.T. Ngadjui
Triumfettamide and Triumfettoside Ic, Two Ceramides and Other Secondary Metabolites from the Stems of Wild Triumfetta cordifolia A. Rich. (Tiliaceae)

J. Het. Chem. 2008, 853
P. Seck, D. Thomae, G. Kirsch

Synthesis 2008, 1600
D. Thomae, G. Kirsch, P. Seck
Synthesis of Selenophene Analogues of the Tacrine Series: Comparison of Classical Route and Microwave Irradiation

J. Het. Chem. 2008, 1, 229-234
T. Kaminski, G. Kirsch
Claisen Condensation of N-Methylpyrrolidinone and α-Chloronicotinic esters

Tetrahedron 2008, 64, 3232-3235
D. Thomae, J.C. Rodriguez Dominguez, G. Kirsch, P. Seck
One Pot Synthesis of Substituted 3-Amino-2-Nitro Thiophenes and Selenophenes.

J. Het. Chem. 2008, 1, 161-164
F Dufour, G. Kirsch
Carbazolo[2,1-a]carbazole Derivatives via Fischer Indole Synthesis

Synlett 2008, 2, 286-288
JC Rodriguez-Dominguez, D. Thomae, P. Seck, G. Kirsch
A Useful One-Pot Procedure for Obtaining 2-Aryl-5-nitrothiophenes from Bromonitromethane and 3-Aryl-3-chloro-propenals

Arkivoc 2008, part vii, 84-91
A. Begouin, S. Hesse, G. Kirsch
Synthesis of benzothienopyridopyrimidinones and benzothienopyrimidoisoquinolinone by microwave-assisted dehydrogenation of the corresponding tetrahydro derivatives

J. Het. Chem. 2008, 1-7
E.-D. Chenot, J.C. Rodriguez Dominguez, P. Hannewald, A. Comel, G. Kirsch Synthesis of Potentially Photoactivatable Coumarin Derivatives via a 1,3-Dipolar Cycloaddition.

2007 (17)

Arkivoc 2007, part x, 374-380
L.A. Ba, G. Kirsch, J. Castello
Synthesis of new substituted thieno[2,3-d]imidazolone from hydantoin

Tetrahedron 2007, 13000-13005
M.J. Queiroz, R.C. Calhelha, G. Kirsch
Reactivity of several deactivated 3-aminobenzo[b]thiophenes in the Buchwald–Hartwig C–N coupling. Scope and limitations

Synlett 2007, 2121-2123
D.Bernardi, L.A. Ba and G.Kirsch
One-pot preparation of 2-(alkyl)arylbenzothiazoles from the corresponding o-halobenzanilides

Tetrahedron Letters 2007, 5777-5780
J.C. Rodriguez-Dominguez, D. Bernardi, G. Kirsch
ZrCl4 or ZrOCl2 under neat conditions: optimized green alternatives for the Biginelli reaction.

Tetrahedron Letters 2007, 48(30), 5261-5264
S. Hesse, E. Perspicace, G. Kirsch
Microwave-assisted synthesis of 2-aminothiophene-3-carboxylic acid derivatives, 3H-thieno [2,3-d]pyrimidin-4-one and 4-chlorothieno[2,3-d]pyrimidine.

Synthesis 2007, 2153-2156
D. Thomae, G.Kirsch, P.Seck and T. Kaminski
One-pot synthesis of 7-hydroxythieno[3,2-b]pyridine5(4H)ones.

Journal of Photochemistry and Photobiology A: Chemistry 2007, 190, 47-52
M.-J.R.P. Queiroz, E.M.S. Castanheira, T.C.T. Lopes, Y.K. Cruz, G. Kirsch
Synthesis of fluorescent tetracyclic lactams by a “one pot” three steps palladium-catalyzed borylation, Suzuki coupling (BSC) and lactamization: DNA and polynucleotides binding studies.

Synthesis 2007, 1571-1575
S. Hesse and G. Kirsch
Buchwald-Hartwig amination of β-chloro accroleins by lactams and heteroarylamines.

Synthesis 2007, 1027-1032
D. Thomae, G. Kirsch and P. Seck
Synthesis of thiophene analogs of Tacrine.

Eur. J. Org. Chem. 2007, 1678-1682
A. Begouin, S. Hesse, M.J. Queiroz and G. Kirsch
Palladium-catalysed Buchwald-Hartwig coupling of deactivated aminothiophenes with substituted halopyridines.

Synthesis 2007, 140-144
D.Bernardi, L.A. Ba and G.Kirsch
First synthesis of N-acylated photoactivatable analogues of glutathione bearing an aryl azide moiety.

Synlett 2007, 649-651
M.A. Lopez-Lopez, A. Balbuzano-Deus, J.C. Rodriguez-Dominguez, M. Mesa Hernandez, A. Fernandez Villalobo, Y. Ibarra Reyes and G. Kirsch
A new synthetic route to 4-methylumbelliferyl--D-glucopyranosiduronic acid (MUG).

J. Heterocyclic Chem. 2007, 44, 273-275
J.C. Rodriguez-Dominguez, A. Balbuzano-Deus, M.A. Lopez-Lopez, G.Kirsch
An improved synthesis of 1-acetyl-1H-indol-3-yl acetates.

Synthetic Communications 2007, 37(3), 483-490
E.-D. Chenot, D. Bernardi, A. Comel, G. Kirsch
Preparation of monoalkylterephtalates: an overview.

Canadian Journal of chemistry 2007, 85(1), 1-6
H.Bekolo, G.Kirsch
Synthesis of substituted 4-azaisoindoles New tacrine analogs.

Canadian Journal of chemistry 2007, 85(1), 42-46
H.Bekolo
Copper mediated N-arylation of electron-deficient pyrroles and indoles.

Magnetic Resonance in Chemistry 2007, 45, 236-239
M.A. Lopez, Z. Rodriguez, M. Gonzalez, B. Tolon, R.Avila, J.C. Rodriguez, H. Velez-Castro, A. Fini
13C NMR spectroscopy of some third generation cephalosporins, synthetic intermediates and reaction by-products

2006 (16)

Org. Prep. & Proced. Int. 2006, 38, 87
A.Balbuzano-Deus, J.C. Rodriguez Dominguez, A. Fernández-Villalobo, M. López-López, G. Kirsch
A Simple Procedure For The Preparation of 6-Chloro-3-Acetoxy-1-Acetylindole.

Synthesis 2006, 509-513
D. Bernardi, A. Dicko, G. Kirsch
New photoactivable analogues of glutathione disulfide

Inorganic Chemistry Communications 2006, 9, 68-71
S. Etienne, M. Beley

Biorg.Med. Chem Letters 2006, 16(6), 1601-1604
D. Bernardi, E. Battaglia, G. Kirsch
Synthesis and evaluation of an N-acetylated photoactivable analogue of glutathione as probe for glutathione utilizing enzymes.

Biorg.Med. Chem. Letters 2006, 16(5), 1384-1387
ICFR Ferreira, MJ. Queiroz, M. Vilas-Boas, LM. Estevinho, A. Begoin, G. Kirsch
Evaluation of the antioxidant properties of diarylamines in the benzo[b]thiophene series by free radical scavenging activity and reducing power.

Z. Naturforsch. 2006,61b, 1-4
G. Kirsch, S. Deprets
Palladium coupling reaction of 3-bromobenzo[b]furan, thiophene and selenophene-2-carbaldehyde. Preparation of tetracyclic heteroaromatic derivatives.

Tetrahedron 2006, 62, 3493-3501
MM. Raposo, AMRC. Sousa, AMC. Fonseca, G. Kirsch
Synthesis of formylthienylpyrroles: versatile building blocks for NLO materials.

Tetrahedron Letters 2006, 47, 3279-3281
JC. Rodriguez-Dominguez, G. Kirsch
Sulfated zirconia, a mild alternative to mineral acids in the synthesis of hydroxycoumarins.

Steroids. 2006, 71(7),599-602.
M. Denance, M. Guyot, M. Samadi

Synthesis 2006, PSP66, 1895-1898
JC. Rodriguez-Dominguez, G. Kirsch
Zirconyl chloride: a useful catalyst in the Pechmann coumarin synthesis.

Synlett 2006, 1021-1022
F. Dufour, G. Kirsch
Efficient synthesis of tetrahydro-1,2,3,4-11H-benzo[a]carbazole and regioselective oxidation.

Journal of photochemistry and photobiology A:Chemistry 2006, 181,290-296
MJRP Queiroz, EMS. Castanheira, AMR. Pinto, ICFR. Ferreira, A. Begouin, G. Kirsch
Synthesis of first thieno-d-carboline. Fluorescence studies in solution and lipid vesicles.

Synthesis 2006, 2794-2798
A. Begouin, S. Hesse, MJRP. Queiroz, G. Kirsch
Reactivity of substituted bromothiophenecarboxylates in palladium-catalyzed N-arylation of hetarylamines.

Bioorg.Med.Chem 2006, 14, 6827-6831
MJRP. Queiroz, ICFR. Ferreira, Y. DeGaetano, G. Kirsch, RC. Calhela, LM. Estevinho

Mater. Sci. Forum 2006, 514-516, 98-102
MMM. Raposo, AMRC. Sousa, A. Mauricio, C. Fonseca, G. Kirsch

Mater. Sci. Forum 2006, 514-516, 103-107
MMM. Raposo, AMRC. Sousa, A. Mauricio, C. Fonseca, G. Kirsch

Université de Lorraine | 03 54 50 54 00 | 34 cours Léopold - CS 25233 - 54 052 Nancy cedex | mentions légales